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Murine Cytomegalovirus CC Chemokine Homolog MCK-2 (m131-129) Is a Determinant of Dissemination That Increases Inflammation at Initial Sites of Infection

2001; American Society for Microbiology; Volume: 75; Issue: 20 Linguagem: Inglês

10.1128/jvi.75.20.9966-9976.2001

1098-5514

Noah Saederup, Shirley A. Aguirre, Tim E. Sparer, Donna M. Bouley, Edward S. Mocarski,

Systemic Lupus Erythematosus Research

ABSTRACT The murine cytomegalovirus CC chemokine homolog MCK-2 (m131-129) is an important determinant of dissemination during primary infection. Reduced peak levels of viremia at day 5 were followed by reduced levels of virus in salivary glands starting at day 7 when mck insertion (RM461) and point (RM4511) mutants were compared to mck -expressing viruses. A dramatic MCK-2-enhanced inflammation occurred at the inoculation site over the first few days of infection, preceding viremia. The data further reinforce the role of MCK-2 as a proinflammatory signal that recruits leukocytes to increase the efficiency of viral dissemination in the host.