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Alkylation of stabilized acetylides in DMSO. Preparation of α,β-acetylenic alcohols and acetals.

1986; Elsevier BV; Volume: 27; Issue: 45 Linguagem: Inglês

10.1016/s0040-4039(00)85233-8

1873-3581

J. Michael Chong, Susanna Wong,

Fluorine in Organic Chemistry

Stabilized terminal acetylenes 1 [e.g. R=CH2OTHP, Ph, CH(OEt)2] may be converted into lithioacetylides and readily alkylated with 1° alkyl halides in DMSO to afford functionalized disubstituted acetylenes.