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Pyridoxine, regardless of serotonin levels, increases production of 5-hydroxytryptophan in rat brain

2004; Elsevier BV; Volume: 35; Issue: 4 Linguagem: Inglês

10.1016/j.arcmed.2004.03.003

1873-5487

David Calderón-Guzmán, José Luis Hernández-Islas, Ivonne Espitia-Vázquez, Gerardo Barragán Mejía, Ernestina Hernández-García, S S Daniel, Hugo Juárez Olguı́n,

Metabolism and Genetic Disorders

The aim of this study was to evaluate effects of pyridoxine and butylated hydroxytoluene (BHT) on lipid peroxidation and on levels of 5-hydroxytryptophan and serotonin.Thirty rats (30 days of age) were used in the survey, measuring levels of lipid peroxidation (TBARS), hemoglobin, 5-hydroxytryptophan (5-HTP), and serotonin (5-HT) after intraperitoneal (i.p.) injections of 4 and 10 mg/kg/day of pyridoxine HCl during 20 days and a single dose of 2 microM/kg (440 microg) of BHT.Levels of TBARS and 5-HTP increased considerably (p <0.05) in all vitamin- and/or BHT-treated groups, and 5-HT increased partially (p <0.05) only in B(6) with or without BHT-treated groups compared with control group.Results suggest that pyridoxine plays a role in tryptophan metabolism, increasing production of 5-HTP.