Evolution of the 4‐anilidopiperidine class of opioid analgesics
1991; Wiley; Volume: 11; Issue: 4 Linguagem: Inglês
10.1002/med.2610110404
ISSN1098-1128
AutoresJerome R. Bagley, Linas V. Kudzma, Nhora L. Lalinde, John A. Colapret, Bao‐Shang Huang, Bor‐Sheng Lin, Thomas P. Jerussi, Mark J. Benvenga, Brian M. Doorley, Michael H. Ossipov, Theodore C. Spaulding, H. Kenneth Spencer, Frieda G. Rudo, Robert Wynn,
Tópico(s)Hormonal and reproductive studies
ResumoMedicinal Research ReviewsVolume 11, Issue 4 p. 403-436 Article Evolution of the 4-anilidopiperidine class of opioid analgesics Jerome R. Bagley, Jerome R. Bagley Department of Chemistry and Department of Pharmacology, Anaquest, Inc., a subsidiary of BOC Health Care, Inc., Murray Hill, New Jersey 07974 Jerome Bagley: graduated from the University of Mississippi at Oxford and obtained a Ph.D. in Medicinal Chemistry for work on rigid analogs of fentanyl and histamine H2-receptor antagonists in 1980. He then did postdoctoral research in the field of triarylethylene antiestrogens at the Department of Medicinal Chemistry, University of Georgia at Athens. He joined Anaquest in 1984 and was appointed manager of the Intravenous Analgesics/Anesthetics Chemistry Section in 1988.Search for more papers by this authorLinas V. Kudzma, Linas V. Kudzma Department of Chemistry and Department of Pharmacology, Anaquest, Inc., a subsidiary of BOC Health Care, Inc., Murray Hill, New Jersey 07974 Linas Kudzma: obtained a M.S. at the Department of Chemistry, Fordham University, New York in 1982 for work on the stereochemistry of tetrahedral hemiorthothioamides. He joined Anaquest in 1983 and was appointed a Principal Scientist in 1990.Search for more papers by this authorNhora L. Lalinde, Nhora L. Lalinde Department of Chemistry and Department of Pharmacology, Anaquest, Inc., a subsidiary of BOC Health Care, Inc., Murray Hill, New Jersey 07974 Nhora Lalinde: obtained a Ph.D. at the Department of Chemistry, City University of New York in 1982 for work on organophosphorous chemistry. She joined Anaquest in 1982 and was appointed a Research Scientist in 1987.Search for more papers by this authorJohn A. Colapret, John A. Colapret Department of Chemistry and Department of Pharmacology, Anaquest, Inc., a subsidiary of BOC Health Care, Inc., Murray Hill, New Jersey 07974 John Colapret: obtained a Ph.D. from the Department of Chemistry, University of Texas at Austin in 1983. He joined Anaquest in 1985. He is now employed with Huls Incorporated, Piscataway, New Jersey.Search for more papers by this authorBao-Shang Huang, Bao-Shang Huang Department of Chemistry and Department of Pharmacology, Anaquest, Inc., a subsidiary of BOC Health Care, Inc., Murray Hill, New Jersey 07974 Bao-Shang Huang: received his Ph.D. from the Department of Chemistry, Mississippi State University at Starksville in 1975 for work in the field of natural products and organic intermediates. He joined Anaquest in 1979 and was appointed a Principal Scientist in 1987.Search for more papers by this authorBor-Sheng Lin, Bor-Sheng Lin Department of Chemistry and Department of Pharmacology, Anaquest, Inc., a subsidiary of BOC Health Care, Inc., Murray Hill, New Jersey 07974 Bor-Sheng Lin: received his Ph.D. from the Department of Chemistry, University of Washington at Seattle in 1983 for work in the field of prostaglandins. He joined Anaquest in 1984 and was appointed Principal Scientist in 1989.Search for more papers by this authorThomas P. Jerussi, Thomas P. Jerussi Department of Chemistry and Department of Pharmacology, Anaquest, Inc., a subsidiary of BOC Health Care, Inc., Murray Hill, New Jersey 07974 Thomas Jerussi: graduated from the Mount Sinai School of Medicine, City University of New York and obtained a Ph.D. in Pharmacology for work on cerebral asymmetry in rats in 1973. He joined Anaquest in 1984 as a Research Pharmacologist and later was promoted to manager of the CNS Pharmacology Section.Search for more papers by this authorMark J. Benvenga, Mark J. Benvenga Department of Chemistry and Department of Pharmacology, Anaquest, Inc., a subsidiary of BOC Health Care, Inc., Murray Hill, New Jersey 07974 Mark Benvenga: obtained a M.S. in Biopsychology from the Department of Psychology, Fordham University, New York in 1983. He joined Anaquest in 1984 and was appointed Research Supervisor in 1990.Search for more papers by this authorBrian M. Doorley, Brian M. Doorley Department of Chemistry and Department of Pharmacology, Anaquest, Inc., a subsidiary of BOC Health Care, Inc., Murray Hill, New Jersey 07974 Brian Doorley: obtained his M.S. from the Department of Pharmacology, St. John's University, New York in 1986 for work in the respiratory effects of opioids. Later that year, he joined the CNS Pharmacology Section of Anaquest. He recently joined Cobe Laboratories, Inc., Arvada, Colorado.Search for more papers by this authorMichael H. Ossipov, Michael H. Ossipov Department of Chemistry and Department of Pharmacology, Anaquest, Inc., a subsidiary of BOC Health Care, Inc., Murray Hill, New Jersey 07974 Michael Ossipov: received his Ph.D. from the Department of Pharmacology, Philadelphia College of Pharmacy and Science in 1982 for work in the field of opioids and alpha-2 adrenergic agonists. He joined Anaquest in 1984 and was appointed leader of the Analgesics Group of the CNS Pharmacology Section in 1988.Search for more papers by this authorTheodore C. Spaulding, Theodore C. Spaulding Department of Chemistry and Department of Pharmacology, Anaquest, Inc., a subsidiary of BOC Health Care, Inc., Murray Hill, New Jersey 07974 Theodore Spaulding: graduated from the University of North Carolina at Chapel Hill and obtained a Ph.D. in Pharmacology in 1973 for work on drug interactions with cannabinoids. He then did postdoctoral research on metabolic interactions between diazepam and methadone in the Department of Pharmacology at the University of Minnesota at Minneapolis, followed by a faculty position in its Biopharmaceutics Department in the School of Pharmacy in 1975. There he studied primidone pharmacokinetics during hepatic dysfunction. In 1977, he joined Hoechst Pharmaceuticals, Somerville, New Jersey, where he attained the position of Group Leader—CNS and Cardiovascular Pharmacology. In 1983, he joined Anaquest as the Director of Pharmacy and Pharmacology.Search for more papers by this authorH. Kenneth Spencer, H. Kenneth Spencer Department of Chemistry and Department of Pharmacology, Anaquest, Inc., a subsidiary of BOC Health Care, Inc., Murray Hill, New Jersey 07974 H. Kenneth Spencer: received his Ph.D. from the Department of Chemistry, University of Georgia at Athens in 1974. He did postdoctoral research at the University of Pennsylvania at Philadelphia in the field of organosulfur chemistry. He later worked for Sandoz Pharmaceuticals Corp. and then Merck- & Co., Inc. He joined Anaquest as the Director of Chemistry in 1983. He has been with Organon Inc., Orange, New Jersey since 1989.Search for more papers by this authorFrieda G. Rudo, Frieda G. Rudo Department of Pharmacology, School of Dentistry, University of Maryland, Baltimore, Maryland 21201 Frieda Rudo: obtained a Ph.D. from the Department of Pharmacology in the School of Medicine, University of Maryland at Baltimore for work in the field of inhalational anesthetics. Since 1957, she has been engaged in inhalational and intravenous anesthetic research for Anaquest at the Department of Pharmacology, School of Dentistry, University of Maryland at Baltimore. She was awarded an honorary doctorate from Gougher College in 1976 for her achievements in the field of inhalational anesthetics and has written chapters in a number of textbooks on this subject.Search for more papers by this authorRichard L. Wynn, Richard L. Wynn Department of Pharmacology, School of Dentistry, University of Maryland, Baltimore, Maryland 21201 Richard Wynn: obtained a Ph.D. from the Department of Pharmacology in the School of Medicine, University of Maryland at Baltiomre in 1969 for work on the teratogenic effects of thalidomide in rats and rabbits. He was Chairman of the Department of Biological Sciences in the School of Dentistry at the University of Kentucky from 1973 to 1980. He has been affiliated with the Department of Pharmacology, School of Dentistry, University of Maryland at Baltimore from 1970 to 1973, and at which he was appointed Chairman of the Department of Pharmacology in 1980. He has been engaged in the development of animal models for drug testing and evaltion of clinical opioids in dentistry.Search for more papers by this author Jerome R. Bagley, Jerome R. Bagley Department of Chemistry and Department of Pharmacology, Anaquest, Inc., a subsidiary of BOC Health Care, Inc., Murray Hill, New Jersey 07974 Jerome Bagley: graduated from the University of Mississippi at Oxford and obtained a Ph.D. in Medicinal Chemistry for work on rigid analogs of fentanyl and histamine H2-receptor antagonists in 1980. He then did postdoctoral research in the field of triarylethylene antiestrogens at the Department of Medicinal Chemistry, University of Georgia at Athens. He joined Anaquest in 1984 and was appointed manager of the Intravenous Analgesics/Anesthetics Chemistry Section in 1988.Search for more papers by this authorLinas V. Kudzma, Linas V. Kudzma Department of Chemistry and Department of Pharmacology, Anaquest, Inc., a subsidiary of BOC Health Care, Inc., Murray Hill, New Jersey 07974 Linas Kudzma: obtained a M.S. at the Department of Chemistry, Fordham University, New York in 1982 for work on the stereochemistry of tetrahedral hemiorthothioamides. He joined Anaquest in 1983 and was appointed a Principal Scientist in 1990.Search for more papers by this authorNhora L. Lalinde, Nhora L. Lalinde Department of Chemistry and Department of Pharmacology, Anaquest, Inc., a subsidiary of BOC Health Care, Inc., Murray Hill, New Jersey 07974 Nhora Lalinde: obtained a Ph.D. at the Department of Chemistry, City University of New York in 1982 for work on organophosphorous chemistry. She joined Anaquest in 1982 and was appointed a Research Scientist in 1987.Search for more papers by this authorJohn A. Colapret, John A. Colapret Department of Chemistry and Department of Pharmacology, Anaquest, Inc., a subsidiary of BOC Health Care, Inc., Murray Hill, New Jersey 07974 John Colapret: obtained a Ph.D. from the Department of Chemistry, University of Texas at Austin in 1983. He joined Anaquest in 1985. He is now employed with Huls Incorporated, Piscataway, New Jersey.Search for more papers by this authorBao-Shang Huang, Bao-Shang Huang Department of Chemistry and Department of Pharmacology, Anaquest, Inc., a subsidiary of BOC Health Care, Inc., Murray Hill, New Jersey 07974 Bao-Shang Huang: received his Ph.D. from the Department of Chemistry, Mississippi State University at Starksville in 1975 for work in the field of natural products and organic intermediates. He joined Anaquest in 1979 and was appointed a Principal Scientist in 1987.Search for more papers by this authorBor-Sheng Lin, Bor-Sheng Lin Department of Chemistry and Department of Pharmacology, Anaquest, Inc., a subsidiary of BOC Health Care, Inc., Murray Hill, New Jersey 07974 Bor-Sheng Lin: received his Ph.D. from the Department of Chemistry, University of Washington at Seattle in 1983 for work in the field of prostaglandins. He joined Anaquest in 1984 and was appointed Principal Scientist in 1989.Search for more papers by this authorThomas P. Jerussi, Thomas P. Jerussi Department of Chemistry and Department of Pharmacology, Anaquest, Inc., a subsidiary of BOC Health Care, Inc., Murray Hill, New Jersey 07974 Thomas Jerussi: graduated from the Mount Sinai School of Medicine, City University of New York and obtained a Ph.D. in Pharmacology for work on cerebral asymmetry in rats in 1973. He joined Anaquest in 1984 as a Research Pharmacologist and later was promoted to manager of the CNS Pharmacology Section.Search for more papers by this authorMark J. Benvenga, Mark J. Benvenga Department of Chemistry and Department of Pharmacology, Anaquest, Inc., a subsidiary of BOC Health Care, Inc., Murray Hill, New Jersey 07974 Mark Benvenga: obtained a M.S. in Biopsychology from the Department of Psychology, Fordham University, New York in 1983. He joined Anaquest in 1984 and was appointed Research Supervisor in 1990.Search for more papers by this authorBrian M. Doorley, Brian M. Doorley Department of Chemistry and Department of Pharmacology, Anaquest, Inc., a subsidiary of BOC Health Care, Inc., Murray Hill, New Jersey 07974 Brian Doorley: obtained his M.S. from the Department of Pharmacology, St. John's University, New York in 1986 for work in the respiratory effects of opioids. Later that year, he joined the CNS Pharmacology Section of Anaquest. He recently joined Cobe Laboratories, Inc., Arvada, Colorado.Search for more papers by this authorMichael H. Ossipov, Michael H. Ossipov Department of Chemistry and Department of Pharmacology, Anaquest, Inc., a subsidiary of BOC Health Care, Inc., Murray Hill, New Jersey 07974 Michael Ossipov: received his Ph.D. from the Department of Pharmacology, Philadelphia College of Pharmacy and Science in 1982 for work in the field of opioids and alpha-2 adrenergic agonists. He joined Anaquest in 1984 and was appointed leader of the Analgesics Group of the CNS Pharmacology Section in 1988.Search for more papers by this authorTheodore C. Spaulding, Theodore C. Spaulding Department of Chemistry and Department of Pharmacology, Anaquest, Inc., a subsidiary of BOC Health Care, Inc., Murray Hill, New Jersey 07974 Theodore Spaulding: graduated from the University of North Carolina at Chapel Hill and obtained a Ph.D. in Pharmacology in 1973 for work on drug interactions with cannabinoids. He then did postdoctoral research on metabolic interactions between diazepam and methadone in the Department of Pharmacology at the University of Minnesota at Minneapolis, followed by a faculty position in its Biopharmaceutics Department in the School of Pharmacy in 1975. There he studied primidone pharmacokinetics during hepatic dysfunction. In 1977, he joined Hoechst Pharmaceuticals, Somerville, New Jersey, where he attained the position of Group Leader—CNS and Cardiovascular Pharmacology. In 1983, he joined Anaquest as the Director of Pharmacy and Pharmacology.Search for more papers by this authorH. Kenneth Spencer, H. Kenneth Spencer Department of Chemistry and Department of Pharmacology, Anaquest, Inc., a subsidiary of BOC Health Care, Inc., Murray Hill, New Jersey 07974 H. Kenneth Spencer: received his Ph.D. from the Department of Chemistry, University of Georgia at Athens in 1974. He did postdoctoral research at the University of Pennsylvania at Philadelphia in the field of organosulfur chemistry. He later worked for Sandoz Pharmaceuticals Corp. and then Merck- & Co., Inc. He joined Anaquest as the Director of Chemistry in 1983. He has been with Organon Inc., Orange, New Jersey since 1989.Search for more papers by this authorFrieda G. Rudo, Frieda G. Rudo Department of Pharmacology, School of Dentistry, University of Maryland, Baltimore, Maryland 21201 Frieda Rudo: obtained a Ph.D. from the Department of Pharmacology in the School of Medicine, University of Maryland at Baltimore for work in the field of inhalational anesthetics. Since 1957, she has been engaged in inhalational and intravenous anesthetic research for Anaquest at the Department of Pharmacology, School of Dentistry, University of Maryland at Baltimore. She was awarded an honorary doctorate from Gougher College in 1976 for her achievements in the field of inhalational anesthetics and has written chapters in a number of textbooks on this subject.Search for more papers by this authorRichard L. Wynn, Richard L. Wynn Department of Pharmacology, School of Dentistry, University of Maryland, Baltimore, Maryland 21201 Richard Wynn: obtained a Ph.D. from the Department of Pharmacology in the School of Medicine, University of Maryland at Baltiomre in 1969 for work on the teratogenic effects of thalidomide in rats and rabbits. He was Chairman of the Department of Biological Sciences in the School of Dentistry at the University of Kentucky from 1973 to 1980. He has been affiliated with the Department of Pharmacology, School of Dentistry, University of Maryland at Baltimore from 1970 to 1973, and at which he was appointed Chairman of the Department of Pharmacology in 1980. He has been engaged in the development of animal models for drug testing and evaltion of clinical opioids in dentistry.Search for more papers by this author First published: July 1991 https://doi.org/10.1002/med.2610110404Citations: 35 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume11, Issue4July 1991Pages 403-436 RelatedInformation
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