The Molecular Pharmacology of Organic Anion Transporters: from DNA to FDA?
2004; American Society for Pharmacology and Experimental Therapeutics; Volume: 65; Issue: 3 Linguagem: Inglês
10.1124/mol.65.3.479
ISSN1521-0111
AutoresSatish A. Eraly, Kevin T. Bush, Rosemary V. Sampogna, Vibha Bhatnagar, Sanjay K. Nigám,
Tópico(s)Metabolism and Genetic Disorders
ResumoRenal organic anion secretion has been implicated in numerous clinically significant drug interactions and adverse reactions, indicating the importance of a detailed understanding of this pathway for the development of optimum therapeutics. With the cloning of multiple genes encoding organic anion transporters (OATs), the study of organic anion secretion has entered the molecular age. In this review, we focus on various aspects of the molecular biology and pharmacology of the OATs, including discussion of their structural biology, genomic organization in pairs, developmental regulation, toxicology, and pharmacogenetics. We propose functional, pathophysiological, and evolutionary hypotheses to help explain recent experimental and genomic data.
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