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BIBTEX RIS

Breakthrough Candidemia Due to Multidrug-Resistant Candida glabrata during Prophylaxis with a Low Dose of Micafungin

2014; American Society for Microbiology; Volume: 58; Issue: 4 Linguagem: Inglês

10.1128/aac.02189-13

ISSN

1098-6596

Autores

Fernando César Bizerra, Cristina Jiménez‐Ortigosa, Ana Carolina Remondi Souza, Giovanni Luís Breda, Flávio Queiroz‐Telles, David S. Perlin, Arnaldo Lopes Colombo,

Tópico(s)

Peptidase Inhibition and Analysis

Resumo

We identified a case of breakthrough candidemia in a 25-year-old patient receiving micafungin prophylaxis (50 mg/day). Five Candida glabrata isolates were obtained from blood cultures and were classified as multidrug-resistant isolates, since all of them exhibited high MICs for echinocandin and azole drugs. A mutation (S663F) in hot spot 1 of the FKS2 gene was found in all five isolates. This mutation yielded a 1,3-β-D-glucan synthase enzyme with highly reduced sensitivities to echinocandin drugs.

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