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Artigo Revisado por pares
BIBTEX RIS

GM‐CSF RAISES SERUM LEVELS OF β 2 ‐MICROGLOBULIN AND THYMIDINE KINASE IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKAEMIA

1996; Wiley; Volume: 94; Issue: 1 Linguagem: Inglês

10.1046/j.1365-2141.1996.6172066.x

ISSN

1365-2141

Autores

Maija Itälä, Tarja‐Terttu Pelliniemi, Kari Remes,

Tópico(s)

Ginkgo biloba and Cashew Applications

Resumo

The effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) on biochemical tumour markers beta 2-microglobulin (beta 2m), thymidine kinase (TK) and lactate dehydrogenase (LDH) were studied in eight patients with chronic lymphocytic leukaemia (CLL). The serum concentration of beta 2m rose by a median of 30% (range 8-50%) and serum TK by 101% (range 30-1414%). Serum LDH concentration, on the other hand, significantly decreased in all patients. The significant increases of beta 2m and TK could not be explained by progression of the disease or impaired renal function. Treatment with GM-CSF reduces the value of serum beta 2m and TK in assessment of tumour mass and disease activity.

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