Intrinsically Copper‐64‐Labeled Organic Nanoparticles as Radiotracers
2012; Wiley; Volume: 51; Issue: 52 Linguagem: Inglês
10.1002/anie.201206939
ISSN1521-3773
AutoresTracy Liu, Thomas D. MacDonald, Jiyun Shi, Brian C. Wilson, Gang Zheng,
Tópico(s)Medical Imaging and Pathology Studies
ResumoAngewandte Chemie International EditionVolume 51, Issue 52 p. 13128-13131 Communication Intrinsically Copper-64-Labeled Organic Nanoparticles as Radiotracers† Tracy W. Liu, Tracy W. Liu Ontario Cancer Institute, Campbell Family Institute for Cancer Research and Techna Institute, UHN (Canada) Department of Medical Biophysics, University of Toronto (Canada) These authors contributed equally to this work.Search for more papers by this authorThomas D. MacDonald, Thomas D. MacDonald Ontario Cancer Institute, Campbell Family Institute for Cancer Research and Techna Institute, UHN (Canada) Department of Pharmaceutical Sciences, University of Toronto (Canada) These authors contributed equally to this work.Search for more papers by this authorDr. Jiyun Shi, Dr. Jiyun Shi Department of Medical Biophysics, University of Toronto (Canada) Medical Isotopes Research Center, Peking University, Beijing (China)Search for more papers by this authorProf.Dr. Brian C. Wilson, Prof.Dr. Brian C. Wilson Ontario Cancer Institute, Campbell Family Institute for Cancer Research and Techna Institute, UHN (Canada) Department of Medical Biophysics, University of Toronto (Canada)Search for more papers by this authorProf.Dr. Gang Zheng, Corresponding Author Prof.Dr. Gang Zheng [email protected] Ontario Cancer Institute, Campbell Family Institute for Cancer Research and Techna Institute, UHN (Canada) Department of Medical Biophysics, University of Toronto (Canada) Department of Pharmaceutical Sciences, University of Toronto (Canada)Ontario Cancer Institute, Campbell Family Institute for Cancer Research and Techna Institute, UHN (Canada)Search for more papers by this author Tracy W. Liu, Tracy W. Liu Ontario Cancer Institute, Campbell Family Institute for Cancer Research and Techna Institute, UHN (Canada) Department of Medical Biophysics, University of Toronto (Canada) These authors contributed equally to this work.Search for more papers by this authorThomas D. MacDonald, Thomas D. MacDonald Ontario Cancer Institute, Campbell Family Institute for Cancer Research and Techna Institute, UHN (Canada) Department of Pharmaceutical Sciences, University of Toronto (Canada) These authors contributed equally to this work.Search for more papers by this authorDr. Jiyun Shi, Dr. Jiyun Shi Department of Medical Biophysics, University of Toronto (Canada) Medical Isotopes Research Center, Peking University, Beijing (China)Search for more papers by this authorProf.Dr. Brian C. Wilson, Prof.Dr. Brian C. Wilson Ontario Cancer Institute, Campbell Family Institute for Cancer Research and Techna Institute, UHN (Canada) Department of Medical Biophysics, University of Toronto (Canada)Search for more papers by this authorProf.Dr. Gang Zheng, Corresponding Author Prof.Dr. Gang Zheng [email protected] Ontario Cancer Institute, Campbell Family Institute for Cancer Research and Techna Institute, UHN (Canada) Department of Medical Biophysics, University of Toronto (Canada) Department of Pharmaceutical Sciences, University of Toronto (Canada)Ontario Cancer Institute, Campbell Family Institute for Cancer Research and Techna Institute, UHN (Canada)Search for more papers by this author First published: 14 November 2012 https://doi.org/10.1002/anie.201206939Citations: 101 † We would like to thank Dr. Warren Foltz for assistance with MR imaging, Tab Siddiqi and Dr. David Green for assistance with the radioUPLC, Dr. Helen Lee, Dr. Jinzi Zhang, and Dr. Wing-Ki Liu for assistance with the pharmacokinetics study, Cheng S. Jin for assistance with the orthotopic prostate cancer model, Dr. David Jaffray and the staff of the STTARR facility for assisting with obtaining 64Cu, and Todd Cunningham for illustrating Figure 2 A. Funding was provided by CIHR, OICR, SERC, CFI, the Princess Margaret Cancer Foundation, MaRS Innovation, Joey and Toby Tanenbaum/Brazilian Ball Chair in Prostate Cancer Research, and the US Army BCRP Predoctoral Award W81XWH-10-1-0115. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract PET friendly: Labels for PET imaging are incorporated into completely organic porphysomes by using a fast (30 min), one-pot, high-yielding (>95 %) procedure to produce highly stable (>48 h) radiolabeled nanoparticles that show the highest specific activity ever reported for a 64Cu-labeled nanoparticle. These 64Cu-porphysomes can be accurately and noninvasively tracked in vivo. Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description anie_201206939_sm_miscellaneous_information.pdf159.8 KB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. 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