Comparison of the effects of etomidate and its fluoro analogue, R 8110, on plasma Cortisol, 11β‐deoxycortisol, 17α‐hydroxyprogesterone and testosterone concentrations in dogs
1987; Wiley; Volume: 10; Issue: 3 Linguagem: Inglês
10.1111/j.1365-2885.1987.tb00533.x
ISSN1365-2885
AutoresR. De Coster, A.‐D. Degryse, P. van Dijk, L. Ooms, E. Lagerweij,
Tópico(s)Diet and metabolism studies
ResumoR 8110, an imidazole derivative, was shown to be clinically superior to etomidate for induction and maintenance of anaesthesia in dogs. The present study compared the effects of intravenous (i.v.) R 8110, etomidate and Ringer solution on cortisol biosynthesis by the adrenal gland in seven male labradors. A tetracosactide challenge was carried out 30 min after the i.v. injection of 3 mg/kg of both drugs and after i.v. Ringer solution (1 ml/kg). Etomidate and R 8110 both suppressed the cortisol response to tetracosactide almost completely and increased the plasma 11 beta-deoxycortisol levels more than 20 fold. Maximal 11 beta-deoxycortisol values were reached 120 min after R 8110, and not less than 300 min after etomidate. Plasma 17 alpha-hydroxyprogesterone and testosterone concentrations did not differ between placebo and R 8110 treatment, but they decreased after etomidate. These results indicate that the effects of R 8110 on steroid biosynthesis in dogs are less pronounced than those of etomidate and are largely limited to a temporary inhibition of the 11 beta-hydroxylase in the adrenal gland.
Referência(s)