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Kinetic Differentiation between Homo‐ and Alternating AT DNA by Sterically Restricted Phosphonium Dyes

2012; Wiley; Volume: 18; Issue: 13 Linguagem: Inglês

10.1002/chem.201102968

1521-3765

Lidija‐Marija Tumir, Ivo Crnolatac, Todor Deligeorgiev, Aleksey Vasilev, Stefka Kaloyanova, Marina Grabar, Sanja Tomić, Ivo Piantanida,

RNA Interference and Gene Delivery

Chemistry – A European JournalVolume 18, Issue 13 p. 3859-3864 Communication Kinetic Differentiation between Homo- and Alternating AT DNA by Sterically Restricted Phosphonium Dyes Dr. Lidija-Marija Tumir, Dr. Lidija-Marija Tumir Division of Organic Chemistry & Biochemistry, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička c. 54, P. O. Box 180, 10002 Zagreb (Croatia)Search for more papers by this authorDr. Ivo Crnolatac, Dr. Ivo Crnolatac Division of Organic Chemistry & Biochemistry, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička c. 54, P. O. Box 180, 10002 Zagreb (Croatia)Search for more papers by this authorProf. Todor Deligeorgiev, Corresponding Author Prof. Todor Deligeorgiev [email protected] Faculty of Chemistry, University of Sofia, J. Bourchier Avenue, 1164, Sofia (Bulgaria) Todor Deligeorgiev, Faculty of Chemistry, University of Sofia, J. Bourchier Avenue, 1164, Sofia (Bulgaria) Sanja Tomić, Division of Organic Chemistry & Biochemistry, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička c. 54, P. O. Box 180, 10002 Zagreb (Croatia) Ivo Piantanida, Division of Organic Chemistry & Biochemistry, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička c. 54, P. O. Box 180, 10002 Zagreb (Croatia)Search for more papers by this authorAleksey Vasilev, Aleksey Vasilev Faculty of Chemistry, University of Sofia, J. Bourchier Avenue, 1164, Sofia (Bulgaria)Search for more papers by this authorDr. Stefka Kaloyanova, Dr. Stefka Kaloyanova Faculty of Chemistry, University of Sofia, J. Bourchier Avenue, 1164, Sofia (Bulgaria)Search for more papers by this authorMarina Grabar Branilović, Marina Grabar Branilović Division of Organic Chemistry & Biochemistry, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička c. 54, P. O. Box 180, 10002 Zagreb (Croatia)Search for more papers by this authorDr. Sanja Tomić, Corresponding Author Dr. Sanja Tomić [email protected] Division of Organic Chemistry & Biochemistry, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička c. 54, P. O. Box 180, 10002 Zagreb (Croatia) Todor Deligeorgiev, Faculty of Chemistry, University of Sofia, J. Bourchier Avenue, 1164, Sofia (Bulgaria) Sanja Tomić, Division of Organic Chemistry & Biochemistry, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička c. 54, P. O. Box 180, 10002 Zagreb (Croatia) Ivo Piantanida, Division of Organic Chemistry & Biochemistry, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička c. 54, P. O. Box 180, 10002 Zagreb (Croatia)Search for more papers by this authorDr. Ivo Piantanida, Corresponding Author Dr. Ivo Piantanida [email protected] Division of Organic Chemistry & Biochemistry, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička c. 54, P. O. Box 180, 10002 Zagreb (Croatia) Todor Deligeorgiev, Faculty of Chemistry, University of Sofia, J. Bourchier Avenue, 1164, Sofia (Bulgaria) Sanja Tomić, Division of Organic Chemistry & Biochemistry, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička c. 54, P. O. Box 180, 10002 Zagreb (Croatia) Ivo Piantanida, Division of Organic Chemistry & Biochemistry, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička c. 54, P. O. Box 180, 10002 Zagreb (Croatia)Search for more papers by this author Dr. Lidija-Marija Tumir, Dr. Lidija-Marija Tumir Division of Organic Chemistry & Biochemistry, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička c. 54, P. O. Box 180, 10002 Zagreb (Croatia)Search for more papers by this authorDr. Ivo Crnolatac, Dr. Ivo Crnolatac Division of Organic Chemistry & Biochemistry, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička c. 54, P. O. Box 180, 10002 Zagreb (Croatia)Search for more papers by this authorProf. Todor Deligeorgiev, Corresponding Author Prof. Todor Deligeorgiev [email protected] Faculty of Chemistry, University of Sofia, J. Bourchier Avenue, 1164, Sofia (Bulgaria) Todor Deligeorgiev, Faculty of Chemistry, University of Sofia, J. Bourchier Avenue, 1164, Sofia (Bulgaria) Sanja Tomić, Division of Organic Chemistry & Biochemistry, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička c. 54, P. O. Box 180, 10002 Zagreb (Croatia) Ivo Piantanida, Division of Organic Chemistry & Biochemistry, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička c. 54, P. O. Box 180, 10002 Zagreb (Croatia)Search for more papers by this authorAleksey Vasilev, Aleksey Vasilev Faculty of Chemistry, University of Sofia, J. Bourchier Avenue, 1164, Sofia (Bulgaria)Search for more papers by this authorDr. Stefka Kaloyanova, Dr. Stefka Kaloyanova Faculty of Chemistry, University of Sofia, J. Bourchier Avenue, 1164, Sofia (Bulgaria)Search for more papers by this authorMarina Grabar Branilović, Marina Grabar Branilović Division of Organic Chemistry & Biochemistry, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička c. 54, P. O. Box 180, 10002 Zagreb (Croatia)Search for more papers by this authorDr. Sanja Tomić, Corresponding Author Dr. Sanja Tomić [email protected] Division of Organic Chemistry & Biochemistry, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička c. 54, P. O. Box 180, 10002 Zagreb (Croatia) Todor Deligeorgiev, Faculty of Chemistry, University of Sofia, J. Bourchier Avenue, 1164, Sofia (Bulgaria) Sanja Tomić, Division of Organic Chemistry & Biochemistry, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička c. 54, P. O. Box 180, 10002 Zagreb (Croatia) Ivo Piantanida, Division of Organic Chemistry & Biochemistry, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička c. 54, P. O. Box 180, 10002 Zagreb (Croatia)Search for more papers by this authorDr. Ivo Piantanida, Corresponding Author Dr. Ivo Piantanida [email protected] Division of Organic Chemistry & Biochemistry, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička c. 54, P. O. Box 180, 10002 Zagreb (Croatia) Todor Deligeorgiev, Faculty of Chemistry, University of Sofia, J. Bourchier Avenue, 1164, Sofia (Bulgaria) Sanja Tomić, Division of Organic Chemistry & Biochemistry, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička c. 54, P. O. Box 180, 10002 Zagreb (Croatia) Ivo Piantanida, Division of Organic Chemistry & Biochemistry, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička c. 54, P. O. Box 180, 10002 Zagreb (Croatia)Search for more papers by this author First published: 24 February 2012 https://doi.org/10.1002/chem.201102968Citations: 21Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Graphical Abstract Poly has a tracker: By sterically controlling monomer–dimer equilibria, novel dyes can kinetically differentiate between homo-AT and alternating AT–AT polynucleotides. In this way, the width and steric occupation of the DNA minor groove can be finely probed and can be easily assessed by induced CD signals (see figure). References 1M. Demeunynck, C. 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Luo, T. Lee, J. Comput. Chem. 2003, 24, 1999– 2012. 17http://amber.scripps.edu/. Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description chem_201102968_sm_miscellaneous_information.pdf997.4 KB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume18, Issue13March 26, 2012Pages 3859-3864 ReferencesRelatedInformation