Produção Nacional
Revisado por pares
Antigenemia for Cytomegalovirus in Renal Transplantation: Choosing a Cutoff For the Diagnosis Criteria in Cytomegalovirus Disease
2005; Elsevier BV; Volume: 37; Issue: 6 Linguagem: Inglês
10.1016/j.transproceed.2005.06.091
ISSN1873-2623
AutoresRoberto Moreira Schroeder, Tatiana Michelon, Iara Fagundes, A. Bortolotto, E. Lammerhirt, J. Oliveira, A. Santos, A.E Bittar, Elizete Keitel, Valter Duro Garcı́a, Jorge Neumann, David Saitovitch,
Tópico(s)Parvovirus B19 Infection Studies
ResumoCytomegalovirus (CMV) infection is a frequent complication in transplant recipients, causing a high level of morbidity and mortality. We studied 203 consecutive renal transplant recipients performed between January 2000 and December 2001. Patients underwent weekly measurements of CMV pp65 antigen to assess CMV activity from the 4th to the 12th week posttransplantation. The results were reported as number of cells positive for the pp65 antigen among 105 granulocytes. In order to define a best cutoff to diagnose CMV disease with desirable sensitivity and specificity, we used a receiver operator characteristics (ROC) curve. The cutoff of four positive cells corresponded to a sensitivity of 93% and specificity of 60% (AUC = 0.87) for the diagnosis of CMV disease. The chosen cutoff for starting antiviral treatment was 10 cells, since this was associated with a sensitivity of 92% and specificity of 70% (AUC = 0.90). In conclusion, the highly sensitive cutoff points for the diagnosis of antigenemia was four cells and 10 cells for initiation of antiviral therapy.
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