A Major Human Histone Gene Cluster on the Long Arm of Chromosome 1
1984; American Association for the Advancement of Science; Volume: 226; Issue: 4676 Linguagem: Inglês
10.1126/science.6494913
ISSN1095-9203
AutoresL Green, Rik van Antwerpen, Janet L. Stein, Gary Stein, P. Tripputi, Beverly S. Emanuel, J.R. Selden, Carlo M. Croce,
Tópico(s)Epigenetics and DNA Methylation
ResumoA human histone gene cluster was assigned to chromosome 1 by Southern blot analysis of DNA's from a series of mouse-human somatic cell hybrids with 32 P -labeled cloned human H4 and H3 histone DNA as probes. Localization of this histone gene cluster on the long arm of chromosome 1 was confirmed by in situ hybridization of this DNA probe to metaphase chromosomes.
Referência(s)