Investigation of terpene diversification across multiple sequenced plant genomes
2014; National Academy of Sciences; Volume: 112; Issue: 1 Linguagem: Inglês
10.1073/pnas.1419547112
ISSN1091-6490
AutoresAlexander M. Boutanaev, Tessa Moses, Jiachen Zi, David R. Nelson, Sam T. Mugford, Reuben J. Peters, Anne Osbourn,
Tópico(s)Natural product bioactivities and synthesis
ResumoSignificance The terpenes are the largest class of plant natural products. This major class of compounds represents tremendous chemical diversity of which only a relatively small fraction has so far been accessed and used by industry. The primary drivers of terpene diversification are terpenoid synthases and cytochromes P450, which synthesize and modify terpene scaffolds. Here, focusing on these two gene families, we investigate terpene synthesis and evolution across 17 sequenced plant genomes. Our analyses shed light on the roots of terpene biosynthesis and diversification in plants. They also reveal that different genomic mechanisms of pathway assembly predominate in eudicots and monocots.
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