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BIBTEX RIS

Differential expression of the MHM region and of sex-determining-related genes during gonadal development in chicken embryos

2014; Research Foundation of Ribeirão Preto; Volume: 13; Issue: 1 Linguagem: Inglês

10.4238/2014.february.13.2

ISSN

1676-5680

Autores

L. C. Caetano, F. G. O. Gennaro, K. I. R. Coelho, Flávio Marcos Gomes Araújo, Reginaldo Aparecido Vila, Antônio César Costa Araújo, Ana de Melo Bernardo, C. R. Marcondes, Susana M. Chuva de Sousa Lopes, Ester Silveira Ramos,

Tópico(s)

Genetic and phenotypic traits in livestock

Resumo

MHM and sex-determining gene expression in chicken embryos SCII, HINTZ, HINTW, and the male hypermethylated (MHM) region.Transcripts for the HINTZ, DMRT1, DAX1, SCII, and SOX9 genes were observed in both sexes, but expression was higher in male gonads and may be correlated with testicular differentiation.The expression patterns of HINTW, SOX3, and MHM suggest that they may act in ovary development and may be involved in meiosis entry.MHM was upregulated and DMRT1 was downregulated in females at the same developmental stage.This may indicate a regulation of DMRT1 by MHM ncRNA.Similar dynamics were observed between HINTW and HINTZ.This study reports on the MHM expression profile during gonadal development and its correlation with the expression of genes involved in vertebrate sex determination.

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