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BIBTEX RIS

Stereospecific Biosynthesis of β‐Methyltryptophan from L ‐Tryptophan Features a Stereochemical Switch

2013; Wiley; Volume: 52; Issue: 49 Linguagem: Inglês

10.1002/anie.201306255

ISSN

1521-3773

Autores

Yi Zou, Qi Fang, Haixing Yin, Zutao Liang, Dekun Kong, Linquan Bai, Zixin Deng, Shuangjun Lin,

Tópico(s)

Enzyme Catalysis and Immobilization

Resumo

Make the switch: The three-enzyme cassette MarG/H/I is responsible for stereospecific biosynthesis of β-methyltryptophan from L-tryptophan (1). MarG/I convert 1 into (2S,3R)-β-methyltryptophan, while MarG/I combined with MarH convert 1 into (2S,3S)-β-methyltryptophan. MarH serves as a stereochemical switch by catalyzing the stereoinversion of the β-stereocenter.

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