HLA antigen familial study in complete Behcet's syndrome affecting three sisters.
1993; BMJ; Volume: 52; Issue: 2 Linguagem: Inglês
10.1136/ard.52.2.155
ISSN1468-2060
AutoresJosé Luis Villanueva‐Cañas, Jaime González‐Domínguez, Raquel González-Fernández, José Luís Prada, José D. Torres‐Peña, Rafael Solana,
Tópico(s)Systemic Lupus Erythematosus Research
ResumoBehçet9s disease is a multisystemic disease affecting most organs. Although a tendency towards an association with a certain genetic type and with HLA-B51 is suspected, the incidence of several siblings with Behçet9s disease in a single family is rare. A family, in which three sisters were affected with Behçet9s disease, uveitis being the most severe manifestation, was studied. In this family all siblings were B51 positive. Only the female siblings, however, with a positive identical HLA phenotype: A2, A11, B51, B44, Cw6, Cw5, DR4, DRw13, DRw53, DRw52, DQw7, DQw6, developed the disease symptoms, whereas none of the male siblings was affected.
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