Portal de Periódicos da CAPES

Light and ultrastructural features of lymphoepithelial lesions of the salivary glands in Mikulicz's disease

1986; Volume: 148; Issue: 3 Linguagem: Inglês

10.1002/path.1711480308

1096-9896

Anand P. Chaudhary, Leslie S. Cutler, G Yamane, Sateesh Satchidanand, Gerald Labay, M SunderRaj,

Vascular Tumors and Angiosarcomas

Abstract This investigation deals with the histogenesis of the so‐called ‘epimyoepithelial islands’ in Mikulicz's disease of the major salivary glands and is based on light and electron microscopic sludy in six patients. The ‘epimyoepithelial islands’ represent collapsed acini prior to their complete involution and disappearance, the intraductal cellular proliferation, stratification and differentiation into luminal and peripheral myoepithelial cells with partial and complete obliteration of their lumina and finally, cord‐like proliferation and formation of nests of residual pluripotential cells showing squamous metaplasia and occasional myoepithelial cell differentiation. A pink, homogenous and hyaline material on light microscopic examination is multilayered and extracellular and is in close association with the basal lamina when viewed with electron microscope.