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Remission induction and maintenance effect of probiotics on ulcerative colitis: A meta-analysis

2010; Baishideng Publishing Group; Volume: 16; Issue: 15 Linguagem: Inglês

10.3748/wjg.v16.i15.1908

2219-2840

Li-Xuan Sang,

Gut microbiota and health

AIM:To evaluate the induction of remission and maintenance effects of probiotics for ulcerative colitis. METHODS:Information was retrieved from MEDLINE, EMBASE, and the Cochrane Controlled Trials Register.The induction of remission and promotion of maintenance were compared between probiotics treatment and non-probiotics treatment in ulcerative colitis. RESULTS:Thirteen randomized controlled studies met the selection criteria.Seven studies evaluated the remission rate, and eight studies estimated the recurrence rate; two studies evaluated both remission and recurrence rates.Compared with the non-probiotics group, the remission rate for ulcerative colitis patients who received probiotics was 1.35 (95% CI: 0.98-1.85).Compared with the placebo group, the remission rate of ulcerative colitis who received probiotics was 2.00 (95% CI: 1.35-2.96).During the course of treatment, in patients who received probiotics for less than 12 mo compared with the group treated by non-probiotics, the remission rate of ulcerative colitis was 1.36 (95% CI: 1.07-1.73).Compared with the non-probiotics group, the recurrence rate of ulcerative colitis patients who received probiotics was 0.69 (95% CI: 2.47-1.01).In the mild to moderate group who received probiotics, compared to the group who did not receive probiotics, the recurrence rate was 0.25 (95% CI: 0.12-0.51).The group who received Bifidobacterium bifidum treatment had a recurrence rate of 0.25 (95% CI: 0.12-0.50)compared with the non-probiotics group. CONCLUSION:Probiotic treatment was more effective than placebo in maintaining remission in ulcerative colitis.