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Update on Recommendations for Assessing Response from the Third International Workshop on Waldenström's Macroglobulinemia

2006; Elsevier BV; Volume: 6; Issue: 5 Linguagem: Inglês

10.3816/clm.2006.n.013

1938-0712

Eva Kimby, Steven P. Treon, Athanasios K. Anagnostopoulos, Meletios Α. Dimopoulos, Ramón García‐Sánz, Morie A. Gertz, Stephen A. Johnson, Véronique Leblond, Jean-Paul Fermand, David G. Maloney, Giampaolo Merlini, Pierre Morel, Enrica Morra, Gwen Nichols, Enrique M. Ocio, Roger G. Owen, Marvin J. Stone, Joan Bladé,

Viral-associated cancers and disorders

This report by an international consensus panel updates current recommendations for defining clinical response in Waldenstrom's macroglobulinemia (WM). The previously published response criteria incorporated parameters for monoclonal protein reduction and/or improvement of marrow and nodal involvement, and included definitions of complete and partial remissions. The criteria have been updated to include minor response and stable disease categories. In addition, the criteria now recognize that delayed responses after treatment with nucleoside analogues and biologic agents and the time point for assessing response in patients with WM should be considered so as to not miss or miscategorize a response. The new criteria should therefore help in better delineating responses to therapy in patients with WM, particularly with the wide use of nucleoside analogues and biologically based agents for this disease.