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Combination Treatment with Noradrenalin and Serotonin Reuptake Inhibitors in Resistant Depression

1992; Cambridge University Press; Volume: 161; Issue: 4 Linguagem: Inglês

10.1192/bjp.161.4.562

1472-1465

Ram Seth, A. L. Jennings, Jonathan Bindman, Jennifer L. Phillips, K. Bergmann,

Electroconvulsive Therapy Studies

Eight cases of resistant recurrent depression were treated with a combination of nortriptyline and a new serotonin reuptake inhbitor, with or without concurrent lithium therapy. Significant improvement was seen in all patients where other drug regimes and ECT had been ineffective. No adverse reactions occurred in any of our patients, seven of whom were elderly. The combination treatment was more effective than individual therapies alone.