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BIBTEX RIS

Cytokine gene variants and venous thrombotic risk in the BRATROS (BRAZILIAN THROMBOSIS STUDY)

2006; Elsevier BV; Volume: 120; Issue: 2 Linguagem: Inglês

10.1016/j.thromres.2006.09.015

1879-2472

Fabiano Pieroni, Dayse Maria Lourenço, Vânia M. Morelli, Francisco Humberto de Abreu Maffei, Marco A. Zago, Rendrik F. Franco,

Coagulation, Bradykinin, Polyphosphates, and Angioedema

Introduction Venous thrombosis (VT) and inflammation are two closely related entities. In the present investigation we assessed whether there is a relation between genetic modifiers of the inflammatory response and the risk of VT. Materials and methods 420 consecutive and unrelated patients with an objective diagnosis of deep VT and 420 matched controls were investigated. The frequencies of the following gene polymorphisms were determined in all subjects: TNF-α−308 G/A, LT-α+252 A/G, IL-6-174 G/C, IL1-ra 86 bp VNTR, IL-10-1082 A/G and CD-31 125 C/G. Results Overall odds ratio (OR) for VT related to TNF-α−308 G/A, LT-α+252 A/G, IL-6-174 G/C, A1 allele (4 bp repeat) of the IL1-ra 86 bp VNTR, IL-10-1082 A/G and CD-31 125 C/G were respectively: 1.0 (CI95: 0.8–1.5), 1.3 (CI95: 1.0–1.7), 1.1 (CI95: 0.9–1.5), 1.6 (CI95: 1–2.5), 1.2 (CI95: 0.8–1.7) and 0.8 (CI95: 0.6–1.1). A possible interaction between polymorphisms was observed only for the co-inheritance of the mutant alleles of the LT-α+252 A/G and IL-10-1082 G/A polymorphisms (OR=2; CI95: 1.1–3.8). The risk of VT conferred by factor V Leiden and FII G20210A was not substantially altered by co-inheritance with any of the cytokine gene polymorphisms. Conclusions Cytokine gene polymorphisms here investigated did not significantly influence venous thrombotic risk.