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BIBTEX RIS

Serine-to-Asparagine Substitution in the GyrA Gene Leads to Quinolone Resistance in Moxifloxacin-Exposed Chlamydia pneumoniae

2004; American Society for Microbiology; Volume: 49; Issue: 1 Linguagem: Inglês

10.1128/aac.49.1.406-407.2005

ISSN

1098-6596

Autores

Jan Rupp, Andreas Gebert, Werner Solbach, Matthias Maass,

Tópico(s)

Pneumonia and Respiratory Infections

Resumo

Quinolone resistance of Chlamydia pneumoniae has not been described previously. Serial subcultures of C. pneumoniae under increasing moxifloxacin concentrations (0.0125 to 6.4 mg/liter) resulted in a 256-fold MIC increase compared to moxifloxacin-naive strains. GyrA gene sequencing revealed a novel point mutation with a Ser-->Asn substitution. Subcultures under rifalazil and macrolides did not alter the respective MICs.

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