Evidence for mobility of a new family of mouse middle repetitive DNA elements (LTR-IS)
1984; Oxford University Press; Volume: 12; Issue: 8 Linguagem: Inglês
10.1093/nar/12.8.3603
ISSN1362-4962
AutoresThomas Wirth, Martin Schmidt, Thomas Baumruker, Ivan D. Horak,
Tópico(s)Trace Elements in Health
ResumoLocus variation and sequence conservation of mouse LTR-IS elements, a new family of middle repetitive DNA sequences was studied. It is shown that LTR-IS sequences are present in all the inbred strains and subspecies of M. musculus tested and in M. cooki and M. caroli . Their arrangement in mouse genomes is polymorphic. Southern blot analysis and DNA sequencing revealed the existence of homologous DNA sequences with and without LTR- IS element insertion. LTR-IS sequences therefore appear to have arisen in early mouse ancestors and have, at least at some point, been mobile.
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