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BIBTEX RIS

Enantioselective Synthesis of (+)-Cephalostatin 1

2009; American Chemical Society; Volume: 132; Issue: 1 Linguagem: Inglês

10.1021/ja906996c

ISSN

1943-2984

Autores

Kevin C. Fortner, Darryl Kato, Yoshiki Tanaka, Matthew D. Shair,

Tópico(s)

Marine Sponges and Natural Products

Resumo

This Article describes an enantioselective synthesis of cephalostatin 1. Key steps of this synthesis are a unique methyl group selective allylic oxidation, directed C−H hydroxylation of a sterol at C12, Au(I)-catalyzed 5-endo-dig cyclization, and a kinetic spiroketalization.

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