Persistence of skin-resident memory T cells within an epidermal niche
2014; National Academy of Sciences; Volume: 111; Issue: 14 Linguagem: Inglês
10.1073/pnas.1322292111
ISSN1091-6490
AutoresAli Zaid, Laura K. Mackay, Azad Rahimpour, Asolina Braun, Marc Veldhoen, Francis R. Carbone, Jonathan H. Manton, William R. Heath, Scott N. Mueller,
Tópico(s)Immunotherapy and Immune Responses
ResumoSignificance Tissue-resident memory T cells (T RM ) form in the skin where they are retained and can protect against subsequent infection. Using a combination of intravital imaging and mathematical modeling of skin T RM that form after cutaneous herpes simplex virus 1 infection, we reveal that these memory T cells persist at the site of infection for the life of a mouse owing to slow random migration. We also report that T RM compete with dendritic epidermal γδ T cells in skin for local survival signals, suggesting that T cells compete for space within an epidermal niche.
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