Nebulization of N-Acetylcysteine Combined with a Bronchodilator in Patients with Chronic Bronchitis
1968; Elsevier BV; Volume: 54; Issue: 6 Linguagem: Inglês
10.1378/chest.54.6.504
ISSN2589-3890
AutoresRoss C. Kory, S HIRSCH, Julian Giraldo,
Tópico(s)Asthma and respiratory diseases
ResumoIn a controlled seven week study in ten patients with chronic obstructive bronchitis, nebulized N-acetylcysteine combined with racemic epinephrine was highly effective in thinning sputum. By contrast, nebulized saline plus racemic epinephrine tended to make the sputum thicker in these same patients. Neither the N-acetylcysteine-racemic epinephrine combination nor the saline-racemic epinephrine aerosol exhibited any observable effect on the chest roentgenogram, spirometric measurements or sputum volume in this group of patients. The bronchial obstruction previously observed with N-acetylcysteine alone did not occur when the drug was nebulized with racemic epinephrine. We would conclude that whenever N-acetylcysteine is administered, a bronchodilator should be nebulized concomitantly unless there is a clear contraindication to its use.
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