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Association of the sirtuin and mitochondrial uncoupling protein genes with carotid intima-media thickness

2012; Elsevier BV; Volume: 160; Issue: 5 Linguagem: Inglês

10.1016/j.trsl.2012.05.010

1931-5244

David Della‐Morte, Chuanhui Dong, Susanne Bartels, Digna Cabral, Susan H. Blanton, Ralph L. Sacco, Tatjana Rundek,

Sirtuins and Resveratrol in Medicine

Sirtuins (SIRTs) are a family of nicotinamide adenine dinucleotide (NAD+)–dependent deacetylases involved in chromatin remodelling, cellular metabolism, and lifespan regulation. 1 Dali-Youcef N. Lagouge M. Froelich S. Koehl C. Schoonjans K. Auwerx J. Sirtuins The "magnificent seven, " function, metabolism and longevity. Ann Med. 2007; 39: 335-345 Crossref PubMed Scopus (361) Google Scholar Uncoupling proteins (UCPs) are a family of inner mitochondrial membrane proteins capable of driving the adenosine triphosphate synthase pathway via regulation of the proton electrochemical gradient. 2 Wolkow C.A. Iser W.B. Uncoupling protein homologs may provide a link between mitochondria, metabolism and lifespan. Ageing Res Rev. 2006; 5: 196-208 Crossref PubMed Scopus (39) Google Scholar SIRTs and UCPs have been implicated in atherosclerosis and cardiovascular disease (CVD) through the control of reactive oxygen species production. 1 Dali-Youcef N. Lagouge M. Froelich S. Koehl C. Schoonjans K. Auwerx J. Sirtuins The "magnificent seven, " function, metabolism and longevity. Ann Med. 2007; 39: 335-345 Crossref PubMed Scopus (361) Google Scholar , 2 Wolkow C.A. Iser W.B. Uncoupling protein homologs may provide a link between mitochondria, metabolism and lifespan. Ageing Res Rev. 2006; 5: 196-208 Crossref PubMed Scopus (39) Google Scholar In our previous in vivo study, the up- or downregulation and the enzymatic activity of SIRT/UCP proteins have been related to the degree of tolerance to brain ischemia. 3 Della-Morte D. Dave K.R. DeFazio R.A. Bao Y.C. Raval A.P. Perez-Pinzon M.A. Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway. Neuroscience. 2009; 159: 993-1002 Crossref PubMed Scopus (323) Google Scholar Therefore, a different alteration in functionality of these proteins may have a different impact on CVD and subclinical atherosclerosis.