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C-peptide and captopril are equally effective in lowering glomerular hyperfiltration in diabetic rats

2004; Oxford University Press; Volume: 19; Issue: 6 Linguagem: Inglês

10.1093/ndt/gfh163

1460-2385

Björn Samnegård, Stefan H. Jacobson, Bo‐Lennart Johansson, Karin Ekberg, B. Isaksson, J. Wahren, M. SJÖQUIST,

Chronic Kidney Disease and Diabetes

Background. C-peptide has been shown to reduce glomerular hyperfiltration, glomerular hypertrophy and urinary albumin excretion in type 1 diabetes, but its effect has not been compared with that of an angiotensin-converting enzyme inhibitor (ACEI) in the early stage of renal involvement in diabetes.