ING116070: A Study of the Pharmacokinetics and Antiviral Activity of Dolutegravir in Cerebrospinal Fluid in HIV-1-Infected, Antiretroviral Therapy-Naive Subjects
2014; Oxford University Press; Volume: 59; Issue: 7 Linguagem: Inglês
10.1093/cid/ciu477
ISSN1537-6591
AutoresScott Letendre, Anthony Mills, Karen T. Tashima, Donald A. Thomas, S. S. Min, S. Chen, In‐Ho Song, Stephen C. Piscitelli,
Tópico(s)Cytomegalovirus and herpesvirus research
ResumoMedian dolutegravir concentrations in cerebrospinal fluid were similar to unbound concentrations in plasma and all subjects exceeded the in vitro 50% inhibitory concentration for wild-type viruses (0.2 ng/mL) by ≥66-fold, suggesting therapeutic concentrations are achieved in cerebrospinal fluid..
Referência(s)