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A Clinical Strain of Escherichia coli Possessing CMY-2 Plasmid-Mediated Amp C β -Lactamase: An Emerging Concern in Pediatrics?

2002; Mary Ann Liebert, Inc.; Volume: 8; Issue: 4 Linguagem: Inglês

10.1089/10766290260469598

1931-8448

Claudia M. Hoyen, Andrea M. Hujer, Kristine M. Hujer, Steven H. Marshall, Lenore L. Carias, Philip Toltzis, Louis B. Rice, Robert A. Bonomo,

Escherichia coli research studies

A 5-year-old child was colonized by an isolate of Escherichia coli that transferred resistance to third-generation cephalosporins and cefoxitin. This resistance phenotype was encoded on a >75-kb plasmid pLRM 22. The transferable plasmid contained both blaCMY-2 and blaTEM-1b. Increasing reports of CMY-2 β-lactamase in clinical isolates in children raise concerns about the empiric use of third-generation cephalosporins in this patient group.