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Regulation of triglyceride biosynthesis in adipose and intestinal tissue

1973; Elsevier BV; Volume: 14; Issue: 4 Linguagem: Inglês

10.1016/s0022-2275(20)36874-7

1539-7262

Diether Polheim, J.S.K. David, F. Michael Schultz, Mary Bob Wylie, John M. Johnston,

Fatty Acid Research and Health

The synthesis of phosphatidic acid and di- and tri- glycerides via the glycerol-3-phosphate pathway is markedly inhibited by 2-monooleyl ether in microsomal and whole cell preparations obtained from adipose and intestinal tissue. Mono- glycerides are also inhibitors under conditions in which their hydrolysis is minimized. A correlation between inhibition by, and the hydrolysis of, monoglycerides has been demonstrated. 2-Monooleyl ether is the most effective inhibitor of the several mono- and di- ethers and esters studied. The specificity of the inhibition of glycerol-3-phosphate acylation by 2-monoethers or 2-monoesters has been demonstrated because microsomal NADH- and NADPH-cytochrome c reductase activities were not significantly inhibited. The reported control mechanism for triglyceride biosynthesis is discussed in relation to the regulation of fatty acid uptake and release in adipose tissue and the ab- sorption and metabolism of triglycerides by the intestinal mucosa.