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Structural Origin of the High Affinity of a Chemically Evolved Lanthanide‐Binding Peptide

2004; Wiley; Volume: 43; Issue: 28 Linguagem: Inglês

10.1002/anie.200460028

1521-3773

Mark Nitz, Manashi Sherawat, Katherine J. Franz, Ezra Peisach, Karen N. Allen, Barbara Imperiali,

Organometallic Complex Synthesis and Catalysis

Playing tag with terbium: New hydrophobic contacts and ligating amino acids are revealed in the 2.0-Å resolution X-ray crystal structure of a chemically evolved 17-residue lanthanide-binding peptide complexed with a Tb3+ ion (see ribbon diagram). The crystal structure agrees well with luminescence-lifetime measurements in solution, which indicate that no first-shell-coordinating water molecules are present in the complex. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z460028_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.