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Kinetics of 201 T1 Uptake in Adenomas and Well-Differentiated Carcinomas of the Thyroid a Double Isotope Investigation with 99 Tc m and 201 T1

1984; Taylor & Francis; Volume: 23; Issue: 1 Linguagem: Inglês

10.3109/02841868409135986

0349-652X

Jan Tennvall, J. Palmer, A. Biörklund, T. Möller, Jonas Ranstam, Måns Åkerman,

Medical Imaging and Pathology Studies

A visually increased uptake of 201Tl chloride corresponding to a 'cold' (131I or 99Tcm ) thyroid nodule is mostly seen in well-differentiated carcinomas but also often in follicular adenomas. Since a visually increased uptake of 201Tl can be due to an increased initial uptake and/or a delayed elimination, an extended dynamic investigation was performed in patients with well-differentiated carcinomas or with follicular adenomas. Data were collected in a dynamic simultaneous double isotope ( 99Tcm + 201Tl) study up to 50 min after intravenous administration. Adenomas could be significantly separated from carcinomas by the elimination (p = 0.0001), but not by the initial uptake.