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Cell Wall Assembly in Saccharomyces cerevisiae

2006; American Society for Microbiology; Volume: 70; Issue: 2 Linguagem: Inglês

10.1128/mmbr.00038-05

1098-5557

Guillaume Lesage, Howard Bussey,

Plant Reproductive Biology

SUMMARY An extracellular matrix composed of a layered meshwork of β-glucans, chitin, and mannoproteins encapsulates cells of the yeast Saccharomyces cerevisiae . This organelle determines cellular morphology and plays a critical role in maintaining cell integrity during cell growth and division, under stress conditions, upon cell fusion in mating, and in the durable ascospore cell wall. Here we assess recent progress in understanding the molecular biology and biochemistry of cell wall synthesis and its remodeling in S. cerevisiae . We then review the regulatory dynamics of cell wall assembly, an area where functional genomics offers new insights into the integration of cell wall growth and morphogenesis with a polarized secretory system that is under cell cycle and cell type program controls.