Recombination between two mouse t -haplotypes ( t w 12 tf and t Lub -1 ): segregation of lethal factors relative to centromere and tufted ( tf ) locus
1983; Cambridge University Press; Volume: 42; Issue: 3 Linguagem: Inglês
10.1017/s0016672300021819
ISSN1469-5073
AutoresHubert Condamine, Jean‐Louis Guénet, François Jacob,
Tópico(s)Genetic diversity and population structure
ResumoSUMMARY Recombination between two mouse t –haplotypes, t w 12 tf and t Lub -1 , was investigated by screening the tailless progeny of the cross ♀ t w 12 tf / t Lub -1 + × ♂ Ttf /+ tf for the segregation of tufted phenotype, t w 12 and t Lub -1 lethal factors, and metacentric chromosome (since t Lub -l haplotype is associated with a Robertsonian fusion involving chromosomes 4 and 17). The results give a 17% estimate of the recombination frequency between centromere and tf , with t Lub -l lethal factor mapping about two-thirds of the distance from centromere to tf and the t w 12 lethal factor behaving as if closely linked to tf . This further extends the findings of Silver & Artzt (1981) and of Artzt, McCormick & Bennett (1982), and shows that two t –haplotypes with quite independent laboratory histories recombine at a normal level, supporting the notion that all t –haplotypes basically share the same structure.
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