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The plasminogen activator inhibitor (PAI)‐1 promoter 4G/4G genotype is not associated with ischemic stroke in a population of German children

2001; Wiley; Volume: 66; Issue: 1 Linguagem: Inglês

10.1034/j.1600-0609.2001.00338.x

1600-0609

Ulrike Nowak‐Göttl, Ronald Sträter, Andrea Kosch, Arnold von Eckardstein, R. Schobeß, Petra Luigs, Petra Nabel, H. Vielhaber, Karin Kurnik, Ralf Junker,

Lipoproteins and Cardiovascular Health

Abstract: Objectives : To investigate the relationship between an insertion/deletion (4G/5G) polymorphism of the plasminogen activator inhibitor (PAI)‐1 gene and childhood patients with a past history of ischemic stroke. Methods : The PAI‐1 4G/4G genotype and the coinheritance with lipoprotein (Lp) (a) levels, the factor V (FV) G1691A mutation, the prothrombin (PT) G20210A variant, and the methylenetetrahydrofolate reductase (MTHFR) T677T genotype were studied in 198 Caucasian children with stroke and 951 controls (same age, sex and ethnical distribution). In a randomly selected subgroup of patients/controls ( n =60) PAI‐1 activities have been investigated. Results : The distribution of the 4G/5G genotypes was no different in childhood stroke patients and controls, with a 4G allele frequency of 55.8% in patients compared with 53.8% in control subjects ( P =0.49). The 4G/4G genotype compared with the remaining genotypes was present in 43 cases and 167 (17.6% vs. 21.7%; OR/CI: 1.30/0.89–1.98; P =0.3). PAI‐1 activity was significantly elevated ( P <0.001) in the patient group. Conclusions : Data presented here suggest that the 4G/4G genotype is not a major risk factor in the aetiology of childhood ischemic stroke.