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Layer-by-Layer Biomolecular Assemblies for Enzyme Sensors, Immunosensing, and Nanoarchitectures

2003; Taylor & Francis; Volume: 36; Issue: 12 Linguagem: Inglês

10.1081/al-120024632

1532-236X

Mònica Campàs, Ciara O’Sullivan,

Nanofabrication and Lithography Techniques

Abstract Layer-by-Layer (LbL) assemblies are multi-modular constructions created on solid substrate mainly via electrostatic interactions between polyanions and polycations. The LbL approach can be used for the inter-layer immobilization of biomolecules with enhanced properties for biocatalytic and immunosensing applications, and to create nanoarchitectures for drug encapsulation and release systems. This LbL approach is generic and provides a strategy to rationally design the properties of immobilized films. The following review reports on the LbL state-of-the-art, characterization techniques, applications in biosensing, and nanoarchitectures.