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Cytokine levels in sites of chronic periodontitis of poorly controlled and well‐controlled type 2 diabetic subjects

2010; Wiley; Volume: 37; Issue: 12 Linguagem: Inglês

10.1111/j.1600-051x.2010.01624.x

1600-051X

Vanessa Renata Santos, Fernanda Vieira Ribeiro, Jadson Almeida Lima, Marcelo Henrique Napimoga, Marta Ferreira Bastos, Poliana Mendes Duarte,

Salivary Gland Disorders and Functions

Santos VR, Ribeiro FV, Lima JA, Napimoga MH, Bastos MF, Duarte PM: Cytokine levels in sites of chronic periodontitis of poorly controlled and well‐controlled type 2 diabetic subjects. J Clin Periodontol 2010; doi: 10.1111/j.1600‐051X.2010.01624.x . Abstract Aim: This study compared the levels of tumour necrosis factor (TNF)‐ α , interferon (IFN)‐ γ , interleukin (IL)‐4, IL‐17 and IL‐23 in the gingival crevicular fluid (GCF) from well‐controlled and poorly controlled type 2 diabetic subjects with chronic periodontitis, before and after periodontal therapy. Material and Methods: Eighteen well‐controlled (glycated haemoglobin levels 8%) and 20 poorly controlled (glycated haemoglobin levels >8%) diabetic subjects were enrolled in this study. All subjects were submitted to non‐surgical periodontal therapy. GCF sampling and clinical periodontal parameters were assessed before, 3 and 6 months post‐therapy. Total amounts and concentrations of TNF‐ α , IFN‐ γ , IL‐4, IL‐17 and IL‐23 in the GCF were analysed by enzyme‐linked immunosorbent assay (ELISA). Results: The levels of IL‐17 were higher in poorly than in well‐controlled subjects ( p <0.05), whereas the levels of IFN‐ γ were increased in well‐ compared with poorly controlled subjects at all experimental groups ( p <0.05). In addition, IL‐4 levels were lower in well‐ than poorly controlled diabetic subjects at baseline ( p <0.05). There were no differences between groups for TNF‐ α and IL‐23 at any time points ( p >0.05). Conclusion: These results indicate a predominance of pro‐inflammatory T‐helper type 1 (Th1)‐ or Th17‐cytokines in sites of chronic periodontitis from type 2 diabetic subjects, according to their glycaemic control.