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BIBTEX RIS

Effects of the serjania erecta and zeyheria montana ethanol extracts in experimental pulpitis in rats: A histological study

2012; Medicina Oral S.L.; Linguagem: Inglês

10.4317/medoral.18470

1698-6946

PM. Nossa, LC. Guenka, LB. Couto, Danyel Elias da Cruz Pérez,

Phytochemistry and Bioactive Compounds

The aim of this study was to evaluate, by the semi-quantitative histological analysis, the anti-inflammatory activity of the ethanolic extracts of Serjania erecta e Zeyheria Montana, in experimental pulpits in rats.In order to induce pulp inflammation, cavities were performed on the occlusal surface of the mandibular first molars of 45 male rats, without pulp exposure. The animals were distributed into 4 groups: GI, teeth without cavities; GII, single dose of saline solution via intraperitoneal (IP); GIII, single dose (IP) of 300 mg/Kg of ethanolic extract of Zeyheria montana; GIV, single dose (IP) of 300 mg/Kg of ethanolic extract of Serjania erecta. After 6, 12 and 24 hours, 5 animals of each group were killed by anesthetic overdose. The histological analyses of the pulp tissue were performed and the data analyzed by Dunn's multiple test, at significance of 5%.After 12 h, the GIII presented score statistically lower (p<0.05) than positive control group. After 24 h, GIII presented inflammatory index statistically lower than the positive control (p<0.01) and Serjania erecta (p<0.05) groups.The Zeyheria montana extract presented better anti-inflammatory activity than positive control group and Serjania erecta extract, which did not show anti-inflammatory effect in the analyzed periods.