P4–414: Caregivers can recognize therapeutic effects from improvements in dementia patients' volition and activity
2013; Wiley; Volume: 9; Issue: 4S_Part_22 Linguagem: Inglês
10.1016/j.jalz.2013.08.247
ISSN1552-5279
Autores Tópico(s)Pharmaceutical Practices and Patient Outcomes
ResumoIt is said that only a few caregivers recognize pharmacotherapeutic effects on dementia. Our outpatient caregivers, however, tell us that they can often see therapeutic effects based on improvements in their patients' volition and activity. Objectives: To investigate factors allowing caregivers to recognize pharmacotherapeutic effects, and to assess improvements which allow caregivers to see therapeutic effects after administration of a cholinesterase inhibitor (ChE-I). The subjects were 55 Alzheimer-type dementia (AD) patients aged 54–91 years with a disease duration of 1–10 years and a educational period of 6–18 years. Before and after administration of ChE-I, MMSE and CIBIC-J-Plus (Mental Function Impairment Scale (MENFIS) and Disability Assessment for Dementia(DAD) scores were evaluated through statistical processing employing the Student t -test in order to examine factors allowing caregivers to recognize drug effects. After the administration of ChE-I, neither MMSE nor DAD changed but the MENFIS total score was improved with statistical significance. Volition and activity especially were improved in many of the patients.
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