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Synthesis of a new substituted zinc phthalocyanine as functional monomer in the preparation of MIPs

2006; World Scientific; Volume: 10; Issue: 08 Linguagem: Inglês

10.1142/s1088424606000417

1099-1409

Luigia Longo, Giuseppe Vasapollo, Anna Scardino, Rosaria Anna Picca, Cosimino Malitesta,

Luminescence and Fluorescent Materials

A new zinc phthalocyanine peripherally substituted with methacrylic groups was synthesized to be employed as a functional monomer in the formation of molecularly imprinted polymers as nucleoside receptors. The binding affinity and selectivity of the synthesized phthalocyanine towards nucleosides were evaluated by UV-vis titration experiments in CH 2 Cl 2 at 298 K. The binding constant ( K a ) and Gibbs free energy changes (-Δ G 0 ) were calculated according to the modified Benesi-Hildebrand equation. Binding experiments showed that K a of phthalocyanine with tri-O-acetyladenosine ( TOAA ) is 1.35 × 10 4 , 500 times that of phthalocyanine with tri-O-acetyluridine ( TOAU ), indicating a high selectivity of the synthesized phthalocyanine derivative.