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Aberrant expression of the negative costimulator PD-1 on T cells in granulomatosis with polyangiitis

2012; Oxford University Press; Volume: 51; Issue: 7 Linguagem: Inglês

10.1093/rheumatology/kes034

1462-0332

Benjamin Wilde, Hua Fan, Sebastian Dolff, Jun Chen, Xin Cai, Christof Specker, Thorsten Feldkamp, Andreas Kribben, J. W. Cohen Tervaert, Oliver Witzke,

Mast cells and histamine

Objective. Persistent T-cell activation is frequently observed in granulomatosis with polyangiitis (GPA, formerly known as Wegener's granulomatosis). T-cell activation is usually balanced by negative costimulatory molecules. The negative costimulator programmed death receptor-1 (PD-1) and its relevance to T-cell immunity have not been studied so far in GPA. Thus it is the aim of the study to characterize the role of PD-1 in GPA.