The effects of ovarian extracts upon activity of the guinea pig uterus in situ.
1953; National Institutes of Health; Volume: 107; Issue: 2 Linguagem: Inglês
Autores
Felton Lc, Frieden Eh, Bryant Hh,
Tópico(s)Pregnancy-related medical research
ResumoStudies of the chemical properties of a uterine relaxing factor (URF), obtained from aqueous extracts of sows9 ovaries indicate that the active agent is non-dialyzable, stable to heat, and sensitive to the action of proteolytic enzymes and a variety of reducing agents. It is concluded that URF is a protein or polypeptide. URF activity is also displayed by both crude and purified relaxin preparations, and comparison of the occurrence of URF and relaxin in various tissues suggests a close relationship between the two substances. The possible relationship of protein-like hormones of the reproductive tract to changes in uterine motility have been discussed.
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