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A GLOBAL INDEX REPRESENTING THE STABILITY OF MALARIA TRANSMISSION

2004; American Society of Tropical Medicine and Hygiene; Volume: 70; Issue: 5 Linguagem: Inglês

10.4269/ajtmh.2004.70.486

1476-1645

Anthony E. Kiszewski, Andrew D. Mellinger, Andrew Spielman, Pia N. Malaney, Sonia Ehrlich Sachs, Jeffrey D. Sachs,

Computational Drug Discovery Methods

To relate stability of malaria transmission to biologic characteristics of vector mosquitoes throughout the world, we derived an index representing the contribution of regionally dominant vector mosquitoes to the force of transmission. This construct incorporated published estimates describing the proportion of blood meals taken from human hosts, daily survival of the vector, and duration of the transmission season and of extrinsic incubation. The result of the calculation was displayed globally on a 0.5° grid. We found that these biologic characteristics of diverse vector mosquitoes interact with climate to explain much of the regional variation in the intensity of transmission. Due to the superior capacity of many tropical mosquitoes as vectors of malaria, particularly those in sub-Saharan Africa, antimalaria interventions conducted in the tropics face greater challenges than were faced by formerly endemic nations in more temperate climes.