Cytotoxic T lymphocytes in HIV-1 infection: a killing paradox?
1998; Elsevier BV; Volume: 19; Issue: 7 Linguagem: Inglês
10.1016/s0167-5699(98)01288-2
ISSN1355-8242
AutoresMichèl R. Klein, Sjoerd H. van der Burg, Oscar Pontesilli, Frank Miedema,
Tópico(s)HIV/AIDS Research and Interventions
ResumoA decade after the first publications on HIV-1-specific cytotoxic T lymphocytes (CTLs) their role in the pathogenesis of AIDS is still equivocal. There is an ongoing debate as to whether HIV-1-specific CTLs control the viremia or mediate CD4+ T-cell depletion and progression to AIDS. However, experimental data in favour of a beneficial role of HIV-1-specific CTLs are mounting. Here, Michèl Klein and colleagues try to depict and reconcile the current paradoxes of HIV-1-specific CTL responses.
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