Portal de Periódicos da CAPES

PRISM: protein interactions by structural matching

2005; Oxford University Press; Volume: 33; Issue: Web Server Linguagem: Inglês

10.1093/nar/gki585

1362-4962

Utkan Ogmen, Özlem Keskin, Ali Selim Aytuna, Ruth Nussinov, Attila Gürsoy,

Enzyme Structure and Function

Prism ( http://gordion.hpc.eng.ku.edu.tr/prism ) is a website for protein interface analysis and prediction of putative protein–protein interactions. It is composed of a database holding protein interface structures derived from the Protein Data Bank (PDB). The server also includes summary information about related proteins and an interactive protein interface viewer. A list of putative protein–protein interactions obtained by running our prediction algorithm can also be accessed. These results are applied to a set of protein structures obtained from the PDB at the time of algorithm execution (January 2004). Users can browse through the non-redundant dataset of representative interfaces on which the prediction algorithm depends, retrieve the list of similar structures to these interfaces or see the results of interaction predictions for a particular protein. Another service provided is interactive prediction. This is done by running the algorithm for user input structures.