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Artigo Acesso aberto Produção Nacional
BIBTEX RIS

Vitamin D Deficiency in HIV-Infected Women on Antiretroviral Therapy Living in the Tropics

2011; SAGE Publishing; Volume: 10; Issue: 4 Linguagem: Inglês

10.1177/1545109711399657

ISSN

1557-0886

Autores

Tereza Conrado, Demócrito de Barros Miranda-Filho, Ricardo Arraes de Alencar Ximenes, Maria de Fátima Pessoa Militão de Albuquerque, Heloísa Ramos Lacerda, Regina Coeli Ferreira Ramos, Paulo Sérgio Ramos de Araújo, Ulísses Ramos Montarroyos, Francisco Bandeira,

Tópico(s)

Pharmacological Effects and Toxicity Studies

Resumo

The effects of HIV/AIDS and antiretroviral drugs on vitamin D metabolism are still mostly unknown. This was a cross-sectional study to estimate the prevalence of vitamin D deficiency and identify its association with the clinical and metabolic parameters among 214 HIV-positive female patients on antiretroviral therapy (ART) in Brazil. The prevalence of vitamin D deficiency (< 30 ng/ml) was 40.65% (87/214). Hypercholesterolemia, high LDL-c, duration of use of current antiretroviral regimen, hypertriglyceridemia, body mass index, age, hypertension, time with AIDS ≥ 10 years and hyperglycemia were selected for multivariate analysis (p < 0.20). After this analysis, hypercholesterolemia and use of current antiretroviral regimen ≥ 3 years remained independently associated with vitamin D deficiency. There was an inverse statistically significant correlation between total cholesterol and serum 25(OH)D levels. High prevalence of vitamin D deficiency was found among HIV-positive women on ART and was independently associated with its prolonged use and with hypercholesterolemia.

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