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Antioxidants and biomarkers of oxidative damage in the saliva of patients with Down's syndrome

2014; Elsevier BV; Volume: 60; Issue: 4 Linguagem: Inglês

10.1016/j.archoralbio.2014.09.013

1879-1506

Michelle Cardoso de Sousa, Rafael Brizola Vieira, Danielle Sá dos Santos, Cláudio Antônio Talge Carvalho, Samira Esteves Afonso Camargo, Maria Nadir Gasparoto Mancini, Luciane Dias de Oliveira,

Oral microbiology and periodontitis research

The aim of this study was to investigate enzymatic and non-enzymatic antioxidant systems and levels of biomarker levels of oxidative damage in the saliva of patients with Down's syndrome (DS).Saliva samples were collected from 30 patients with DS and control group (age: 14-24 years). Subsequently, the concentrations of superoxide dismutase, concentration of malondialdehyde, carbonylated proteins, uric acid, vitamin C and total protein, peroxidase activity and total antioxidant capacity were analyzed.Patients with DS presented significantly higher concentrations of superoxide dismutase, higher levels of malondialdehyde and salivary total protein content than controls (p 0.05).Patients with DS are more vulnerable to oxidative stress in saliva as indicated by the significant increase in malondialdehyde and superoxide dismutase concentrations found in this study.