Artigo Acesso aberto Revisado por pares

A Common Mutation in the Defensin DEFB126 Causes Impaired Sperm Function and Subfertility

2011; American Association for the Advancement of Science; Volume: 3; Issue: 92 Linguagem: Inglês

10.1126/scitranslmed.3002289

ISSN

1946-6242

Autores

Theodore L. Tollner, Scott A. Venners, Edward J. Hollox, Ashley I. Yudin, Xue Liu, Genfu Tang, Houxun Xing, Robert J. Kays, Tsang Lau, James W. Overstreet, Xiping Xu, Charles Bevins, Gary N. Cherr,

Tópico(s)

Plant Reproductive Biology

Resumo

A frequent frameshift mutation in defensin DEFB126 , a protein that adheres to the surface of human sperm, weakens its ability to penetrate cervical mucus-like gels and causes low fertility.

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