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Impact of Clinical and Histopathological Parameters on Disease Specific Survival in Patients with Collecting Duct Renal Cell Carcinoma: Development of a Disease Specific Risk Model

2013; Lippincott Williams & Wilkins; Volume: 190; Issue: 2 Linguagem: Inglês

10.1016/j.juro.2013.02.035

1527-3792

Matthias May, Vincenzo Ficarra, Shahrokh F. Shariat, Richard Zigeuner, Thomas Chromecki, Luca Cindolo, Maximilian Burger, Sven Gunia, Bogdan Feciche, Valentina Wenzl, Atiqullah Aziz, Felix K.‐H. Chun, Andreas Becker, Sascha Pahernik, Claudio Simeone, Nicola Longo, Alessandro Zucchi, Alessandro Antonelli, Vincenzo Mirone, Christian G. Stief, Giacomo Novara, Sabine Brookman‐May,

Bladder and Urothelial Cancer Treatments

No AccessJournal of UrologyAdult Urology1 Aug 2013Impact of Clinical and Histopathological Parameters on Disease Specific Survival in Patients with Collecting Duct Renal Cell Carcinoma: Development of a Disease Specific Risk Model Matthias May, Vincenzo Ficarra, Shahrokh F. Shariat, Richard Zigeuner, Thomas Chromecki, Luca Cindolo, Maximilian Burger, Sven Gunia, Bogdan Feciche, Valentina Wenzl, Atiqullah Aziz, Felix Chun, Andreas Becker, Sascha Pahernik, Claudio Simeone, Nicola Longo, Alessandro Zucchi, Alessandro Antonelli, Vincenzo Mirone, Christian Stief, Giacomo Novara, Sabine Brookman-May, and CORONA and SATURN projects, Young Academic Urologists Renal Cancer Group Matthias MayMatthias May Department of Urology, St. Elisabeth Hospital Straubing, Straubing, Germany , Vincenzo FicarraVincenzo Ficarra Department of Oncologic and Surgical Sciences, University of Padua, Padua, Italy Robotic Surgery Institute, Onze-Lieve-Vrouwziekenhuis Aalst, Aalst, Belgium , Shahrokh F. ShariatShahrokh F. Shariat Department of Urology and Division of Medical Oncology, Weill Cornell Medical College, New York, New York , Richard ZigeunerRichard Zigeuner Department of Urology, Medical University of Graz, Graz, Austria , Thomas ChromeckiThomas Chromecki Department of Urology, Medical University of Graz, Graz, Austria , Luca CindoloLuca Cindolo Department of Urology, S. Pio Da Pietrelcina Hospital, Vasto, Italy , Maximilian BurgerMaximilian Burger Department of Urology, University of Wuerzburg, Wuerzburg, Germany , Sven GuniaSven Gunia Department of Pathology, Johanniter Hospital Stendal, Stendal, Germany , Bogdan FecicheBogdan Feciche Department of Urology, Clinical Municipal Hospital, Cluj-Napoca, Romania , Valentina WenzlValentina Wenzl Department of Urology, University of Regensburg, Caritas St. Josef Medical School, Regensburg, Germany , Atiqullah AzizAtiqullah Aziz Department of Urology, University of Regensburg, Caritas St. Josef Medical School, Regensburg, Germany , Felix ChunFelix Chun Department of Urology, Martini-Klinik, University of Hamburg, Hamburg, Germany , Andreas BeckerAndreas Becker Department of Urology, Martini-Klinik, University of Hamburg, Hamburg, Germany , Sascha PahernikSascha Pahernik Department of Urology, University of Heidelberg, Heidelberg, Germany , Claudio SimeoneClaudio Simeone Department of Urology, University of Brescia, Brescia, Italy , Nicola LongoNicola Longo Department of Urology, University Federico II of Naples, Naples, Italy , Alessandro ZucchiAlessandro Zucchi Department of Urology and Andrology, University of Perugia, Perugia, Italy , Alessandro AntonelliAlessandro Antonelli Department of Urology, University of Brescia, Brescia, Italy , Vincenzo MironeVincenzo Mirone Department of Urology, University Federico II of Naples, Naples, Italy , Christian StiefChristian Stief Department of Urology, Klinikum Grosshadern, Ludwig-Maximilians-University Munich, Munich, Germany , Giacomo NovaraGiacomo Novara Department of Oncologic and Surgical Sciences, University of Padua, Padua, Italy , Sabine Brookman-MaySabine Brookman-May Department of Urology, Klinikum Grosshadern, Ludwig-Maximilians-University Munich, Munich, Germany , and CORONA and SATURN projects, Young Academic Urologists Renal Cancer Group View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.035AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Collecting duct renal cell carcinoma is a rare, aggressive histological subtype of renal cell carcinoma. Since few groups have evaluated the oncological prognosis in these patients based on clinical and pathological parameters, we assessed parameters prognostic for disease specific mortality. Materials and Methods: From a cohort of 14,047 patients with renal cell carcinoma we retrieved the records of 95 with collecting duct renal cell carcinoma at a total of 16 European and American centers of the CORONA (Collaborative Research on Renal Neoplasms Association) and SATURN (Surveillance and Treatment Update Renal Neoplasms) projects, and another 2 centers. Multivariable Cox regression analysis was applied to determine the influence of parameters on disease specific mortality. Median followup was 48.1 months (IQR 24–103). Results: The disease specific survival rate at 1, 2, 5 and 10 years was 60.4%, 47.3%, 40.3% and 32.8%, respectively. American Society of Anesthesiologists (ASA) score 3–4, tumor size greater than 7 cm, stage M1, Fuhrman grade 3-4 and lymphovascular invasion independently predicted disease specific mortality. Based on these parameters, patients were divided into 26 (27%) at low, 13 (14%) at intermediate and 56 (59%) at high risk with a 5-year disease specific survival rate of 96%, 62% and 8%, respectively (bootstrap corrected c-index 0.894, 95% CI 0.820–0.967, p <0.001). Conclusions: While patients with collecting duct renal cell carcinoma are commonly diagnosed at advanced stage and have poor prognosis after surgery, a subset has excellent survival. Histopathological features can help risk stratify patients based on the described, highly accurate risk model to predict disease specific mortality, facilitating patient counseling and risk based clinical decision making for adjuvant therapy and clinical trial inclusion. References 1 : Effect of collecting duct histology on renal cell cancer outcome. 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Google Scholar © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 190Issue 2August 2013Page: 458-463Supplementary Materials Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.Keywordscarcinomarenal cellkidneymortalitypathologyprognosisMetricsAuthor Information Matthias May Department of Urology, St. Elisabeth Hospital Straubing, Straubing, Germany More articles by this author Vincenzo Ficarra Department of Oncologic and Surgical Sciences, University of Padua, Padua, Italy Robotic Surgery Institute, Onze-Lieve-Vrouwziekenhuis Aalst, Aalst, Belgium More articles by this author Shahrokh F. Shariat Department of Urology and Division of Medical Oncology, Weill Cornell Medical College, New York, New York More articles by this author Richard Zigeuner Department of Urology, Medical University of Graz, Graz, Austria Financial interest and/or other relationship with Amgen, Astellas, Bayer, GlaxoSmithKline, Pfizer, Novartis and Roche. More articles by this author Thomas Chromecki Department of Urology, Medical University of Graz, Graz, Austria More articles by this author Luca Cindolo Department of Urology, S. Pio Da Pietrelcina Hospital, Vasto, Italy More articles by this author Maximilian Burger Department of Urology, University of Wuerzburg, Wuerzburg, Germany More articles by this author Sven Gunia Department of Pathology, Johanniter Hospital Stendal, Stendal, Germany More articles by this author Bogdan Feciche Department of Urology, Clinical Municipal Hospital, Cluj-Napoca, Romania More articles by this author Valentina Wenzl Department of Urology, University of Regensburg, Caritas St. Josef Medical School, Regensburg, Germany More articles by this author Atiqullah Aziz Department of Urology, University of Regensburg, Caritas St. Josef Medical School, Regensburg, Germany More articles by this author Felix Chun Department of Urology, Martini-Klinik, University of Hamburg, Hamburg, Germany More articles by this author Andreas Becker Department of Urology, Martini-Klinik, University of Hamburg, Hamburg, Germany More articles by this author Sascha Pahernik Department of Urology, University of Heidelberg, Heidelberg, Germany More articles by this author Claudio Simeone Department of Urology, University of Brescia, Brescia, Italy More articles by this author Nicola Longo Department of Urology, University Federico II of Naples, Naples, Italy More articles by this author Alessandro Zucchi Department of Urology and Andrology, University of Perugia, Perugia, Italy More articles by this author Alessandro Antonelli Department of Urology, University of Brescia, Brescia, Italy More articles by this author Vincenzo Mirone Department of Urology, University Federico II of Naples, Naples, Italy More articles by this author Christian Stief Department of Urology, Klinikum Grosshadern, Ludwig-Maximilians-University Munich, Munich, Germany More articles by this author Giacomo Novara Department of Oncologic and Surgical Sciences, University of Padua, Padua, Italy Equal study contribution. More articles by this author Sabine Brookman-May Department of Urology, Klinikum Grosshadern, Ludwig-Maximilians-University Munich, Munich, Germany Equal study contribution. Financial interest and/or other relationship with Janssen. More articles by this author CORONA and SATURN projects, Young Academic Urologists Renal Cancer Group More articles by this author Expand All Advertisement PDF downloadLoading ...